Research Publications 2008

Rodrigues, M.A., Verdile G., Foster J.K., Hogervorst E., Joesbury K., Dhaliwal S., Corder E.H, Laws, S.M., Hone E., Prince, R., Devine A., Mehta, P., Beilby J., Atwood C.S., Martins, R.N. Gonadotropins and Cognition in Older Women. Journal of Alzheimer's Disease. (2008) 13(3) 267-274.

Hsien W.Chan, Tianbing Liu, Giuseppe Verdile, Glenda Bishop, Ryan J Haasl, Mark A Smith, George Perry, Ralph N Martins and Craig S Atwood. Copper Induces Apoptosis of Neuroblastoma Cells via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the txj Mouse is a better Model of Hepatic than Brain Cu Toxicity. International Journal of Clinical and Experimental Medicine (2008) 1:76-88.

Rimajova M., Lenzo NP., Wu JS, Bates KA, Campbell A., Dhaliwal SS, McCarthy M. Rodrigues M., Paton A, Rowe C, Foster JK., Martins RN. Fluoro-2-deoxy-D-glucose (FDG)-PET in APOE epsilon 4 carriers in the Australian population. Journal of Alzheimer's Disease (2008) Vol 13:(2) 137-146.

Flicker L, Martins RN, Thomas J, Acres J, Taddei K, Vasikaran SD, Norman P, Jamrozik K, Almeida OP. B-vitamins reduce plasma levels of beta amyloid. Neurobiology of Aging (2008) 29:303-305.

Verdile G., Yeap B.B., Clarnette R.M., Dhaliwal S., Burkhardt M.S., Chubb S.A.P., De Ruyck K., Rodrigues M., Mheta D. P., Foster J.K., Bruce, D.G. and Martins R.N. (2008). Luteinizing hormone is positively correlated with plasma amyloid-b-protein levels in elderly men. Journal of Alzheimer's Disease. (2008) 14:201-208.

Taddei K., Laws SM., Verdile G., Munns S., D'Costa K., Harvey AR., Martins IJ, Hill F., Levy E., Shaw JE and Martins RN. Novel phage peptides attenuate amyloid-β42 catalysed hydrogen peroxide production and associated neurotoxicity. Neurobiology of Aging (2008) (Accepted 31/3/08)

Miklossy J., and Martins RN. Chronic Inflammation and Amyloidgenesis in Alzheimer's Disease: The emerging Role of Infection. Journal of Alzheimer's Disease. (2008) 13(4) 357.

Urosevic N. and Martins RN. Infection and Alzheimer's Disease: The APOE ε4 Connection and Lipid Metabolism. Journal of Alzheimer's Disease. (2008) 13 (4) 421-435.

Bates KA, Verdile G. Q-X Li, Ames D, Hudson P, Masters CL and Martins RN. Clearance mechanisms of Alzheimer's amyloid-β peptide: implications for therapeutic design and diagnostic tests. Feature Review Molecular Psychiatry (2008) e pub head of publication 16 September 08.

Gnjec A, D'Costa K, Laws SM, Hedley R, Balakrishan K. Martins G, Paton A, Verdile G, Gandy SE, Broe GA, Brooks WS, Bennett H, Piguet O, Price P, Miklossy J, Hallmayer J, McGeer PL, Martins RN Association of alleles carried at TNFA -850 and BATI -22 with Alzheimer's disease. Journal of Neuroinflammation (2008) 5:36

Wahjoepramono EJ, Wijaya LK, Taddei K, Martins G, Howard M, de Ruyck K, Bates K, Dhaliwal SS, Verdile G, Carruthers M, Martins RN. Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-β levels. Journal of Alzheimer's Disease. (2008) 15:129-137.

Sohrabi HR, Bates KA, Rodrigues M, Taddei K, Martins G, Laws SM, Lautenschlager NT, Dhaliwal SS, Foster JK, Martins RN. The relationship between memory complaints, perceived quality of life and mental health in apolipoprotein Eε4 carriers and non-carriers? Journal of Alzheimer' s disease, (2008) Accepted for publication October.

Bharadwaj PR, Dubey AK, Masters CL, Martins RN, Macreadie IA. Aβ aggregation and possible implication in Alzheimer's disease pathogenesis. Journal of Cellular and Molecular Medicine. (2008) Accepted for publication October.

Foster JK, Sohrabi HR, Verdile G, Martins RN. Research criteria for the diagnosis of Alzheimer's disease: genetic risk factors, blood biomarkers and olfactory dysfunction. International Psychogeriatrics. (2008) 20(4):253-255.

De Silva R, Disanayak S, De Zoysa N, Sanjeewanie N, Somaratne S, Foster JK, Srikanth S, Katriarachchi, S, Martins R. Prevalence of cognitive impairment in elders' homes in Sri Lanka. International Journal of Geriatric Psychiatry. (2008) (Accepted October).

Sohrabi HR, Bates KA, Rodrigues M, Taddei K, Laws SM, Lautenschlager NT, Dhaliwal SS, Johnston ANB, Mackay-Sim A, Foster JK, Martins RN. Olfactory dysfunction is associated with subjective memory complaints in community-dwelling elderly individuals. Journal of Alzheimer's Disease (2008) (In press) Accepted October 2008.

Maczurek A, Hager K, Kenklies M, Sharman M, Martins RN, Engel J, Carlson DA, Munch G. Lipoic acid as an anti-inflammatory and neuroprotective treatment for Alzheimer's disease. Advanced Drug Delivery Reviews (2008) 60:1463-1470.

Miklossy J, Qing H, Radenovic A, Kis A, Vileno B, Làszló F, Miller L, Martins RN, Waeber G, Mooser V, Bosman F, Khalili K, Darbinian-Sarlissian N, McGeer PL. Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes. Neurobiology of Aging. (2008) Oct 16. [Epub ahead of print]

Bates, K.A., Sohrabi, H. R., Rodrigues, M., Beilby, J., Dhaliwal, S.S., Taddei, K., Criddle A., Wraith, M., Howard, M., Martins, G., Paton, A., Mehta, P., Foster, J. K., Martins, I. J., Lautenschlager, N. T., Mastaglia, F., Laws, S. M. and Martins, R. N. "Relationship between cardiovascular disease risk factors and Alzheimer's disease Aβ protein in subjective memory complainers". Journal of Alzheimer's Disease, accepted December 2008.

Barron AM., Verdile G. and Martins RN (2008). The Role of Luteinizing Hormone in Alzheimers Disease. In Gonadal and nongonadal actions of Gonadotropins pp 275-290. Narosa Publishing House Pvt. Ltd, Dehli, India.

Verdile G and Martins RN (2008). The role of gonadotropins and testosterone in the regulation of beta amyloid metabolism. In Hogervorst, Henderson, Gibbs & Brinton (Eds.), Hormones, Cognition and Dementia: State of the Art and Emergent Therapeutic Strategies. Cambridge University Press, Shaftesbury Road, Cambridge CB2 8RU, UK, in press.

Barron, A.M., Taddei, K., Verdile, G. & Martins, R.N. (2008). Time and dose dependent effects of human chorionic gonadotropin on APP processing and beta amyloid levels in the PS1M146V mouse model of Alzheimers disease. Alzheimer's and Dementia. 4(4) S1:T347.

Verdile G and Martins RN (2008). Molecular Genetics of Alzheimers Disease. In Wildenauer D (ed) Molecular Biology of Neuropsychiatric Disorders pp 231-278. Springer-Verlag, Berlin Heidelberg.

Foster JK, Verdile G, Bates KA, Martins RN. Immunization in Alzheimer's disease: naïve hope or realistic clinical potential? Molecular Psychiatry (2009) 14:239-251.

Barron A.M., Cake M., Verdile G., and Martins RN. Ovariectomy and 17b-estradiol replacement do not alter beta amyloid levels in sheep brain. Endocrinology, (2009) in press accepted 4/3/09.

Bates KA, Sohrabi H, Rodrigues M, De Ruyck K, Beilby J, Dhaliwal SS, Criddle A, Wraith M, Howard M, Martins G, Paton A, Mehta P, Foster JK, Martins IJ, Lautenschlager N, Mastaglia FL, Laws SM, Gandy SE, Martins RN Relationship between cardiovascular disease risk factors and Alzheimer's disease ABeta protein in subjective memory complainers. ICAD July/August 2008.

Barron AM, Taddei K, De Ruyck K, Croft KD, Mori T, Verdile G, Martins RN. Time- and dose-dependent effects of ovariectomy and human chronic gonadotropin treatment on beta amyloid and isoprostane levels in the PS1M146V mouse model of Alzheimer's disease. ICAD July/August 2008.

Sohrabi H, Bates KA, Rodrigues M, Taddei K, Laws S, Lautenschlager N, Dhaliwal S, Johnston A, MacKay-Sim A, Foster JK, Martins RN. Frequency of forgetting is associated with olfactory functions in healthy, community-dwelling elderly. ICAD July/August 2008.

Ellis K, Villemagne VL, Ames d, Lenzo N, Pike K, O'Keefe G, Tochon-Danguy H, Price R, Jones G, Rimajova M, Bourgeat P, Raniga P, Fripp J, Salvado O, Martins RN, Masters C, Rowe C. The Australian Biomarker Imaging and Lifestyle Study, Preliminary PIB results. ICAD July/August 2008.

Martins RN, Sharman M, Taddei K, Martins I, Hone E, Berger T. Isoform-specific effects of Apoe on beta-amyloid clearance of beta and lipid metabolism. ICAD (Poster & Oral presentation) July/August 2008.

Ellis KA, Rowe, C, Masters CL, Martins RN, Hudson P, Milner A, Bevege L, Savage G, Ames, D. Baseline data from a multicentre, prospective longitudinal study of ageing in 100 volunteers (The AIBL Study). ICAD July/August 2008.

Ellis KA, Rowe C, Masters CL, Martins RN, Hudson P, Milner A, Bevege L, Ames D.(2008) Baseline Data from the Australian Imaging Biomarkers and Lifestyle Flagship Study of Ageing. DCRC Sept Sydney.

Barron, A.M., Taddei, K., Verdile, G. & Martins, R.N. (2008). Human chorionic gonadotropin elevates beta amyloid levels in a mouse model of Alzheimers disease. The Endocrine Society's 90th Annual Meeting. 13-18 June, 2008 San Francisco, California, USA.